Control of volitional and reflexive saccades in Tourette's syndrome

Control of volitional and reflexive saccades in Tourette's syndrome.

Tourette's syndrome is characterized by involuntary tics and, although the underlying pathogenesis and pathophysiology of Tourette's syndrome remains unclear, it is suspected that basal ganglia structures are involved. The basal ganglia also play an important role in the control of saccadic eye movements and we therefore hypothesize that Tourette's syndrome patients have abnormal control of sac...

Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans.

This review provides a summary of the contributions made by human functional neuroimaging studies to the understanding of neural correlates of saccadic control. The generation of simple visually guided saccades (redirections of gaze to a visual stimulus or pro-saccades) and more complex volitional saccades require similar basic neural circuitry with additional neural regions supporting requisit...

Control of Reflexive Saccades following Hemispherectomy

Individuals who have undergone hemispherectomy for treatment of intractable epilepsy offer a rare and valuable opportunity to examine the ability of a single cortical hemisphere to control oculomotor performance. We used peripheral auditory events to trigger saccades, thereby circumventing dense postsurgical hemianopia. In an antisaccade task, patients generated numerous unintended short-latenc...

Reflexive and volitional saccades: biomarkers of Huntington disease severity and progression.

BACKGROUND Huntington disease (HD) is a genetic, neurodegenerative disorder characterized by chorea, behavioral co-morbidities, cognitive deficits, and eye movement abnormalities. We sought to evaluate whether reflexive and voluntary orienting prove useful as biomarkers of disease severity in HD. METHODS Eleven HD subjects were evaluated with the motor subscale of the Unified Huntington Disea...

Control of Attention before Reflexive and Intentional Saccades